Abstract Paper

Journal of Functional Materials and Bio-molecules

Title : Hypoglycemic Effect of Cnidoscolus acontifoluson Alloxan Induced Diabetes in Albino Wistar Rats
Author(s) : Mamudu Vincent E, Luka Ayuba, Jwan’an Luther E, Ayoade Babalola D
Article Information : Volume 4 - Issue 1 (July - 2020) , 382 – 387
Affiliation(s) : Department of Biochemistry, Bayero University, Kano.
: Department of Microbiology, Bayero University, Kano.
: Department of Biochemistry, University of Ibadan.

Abstract :

Introduction: The potency of plants is largely due to the presence of phytochemicals contained in it; which establishes its efficacy in the treatment of health conditions like diabetes mellitus. Some obvious limitations of the drug management methods necessitate a search for alternatives among the arsenal of herbs available in the natural habitat of man.Aim: Evaluating the hypoglycaemic effect of Cnidoscolus aconitifolus leaveextract on alloxan induced diabetes mellitus and also to evaluate and compare the hypoglycaemic effect of glibenclamide and chloroform, butanol, ethanol extract of Cnidoscolus aconitifolius on alloxan induced diabetes mellitus Albino Wistar Rats.Methods: fifthy (50) wistar rats with average weighing 150-200g, were randomly assigned into tengroups of 5animals each. After one week of acclimatization, diabetes was induced with a single intraperitoneal injection of alloxan at a dose of 60mg/kg body weight. Group 1: Served as Negative control (Non-diabetic) and received normal rat chow and 0.3ml normal saline; Group 2: Served as positive control group; groups 3 and 4served as test, and received butanolic and ethanolic extract of Cnidoscolus aconitifolius leaf extract respectively orally for 28 days. Groups 5, 6, 7 and 8 received 50mg/kg, 100mh/kg, 150mg/kg, and 200mg/kg respectively while group 9 and 10 received 0.1mg/kg and 0.5mg/kg of glibenclamide respectively.Results: A dose dependent reduction in blood glucose level was observed after treatment when compared with glucose level before induction.Conclusion: This study revealed the ability of C. aconitifolius to lower blood glucose level; thereby suggesting that it could serve as a better therapy for diabetes mellitus and paving way for further investigation to identify the actual bioactive compounds responsible.

Keywords : Cnidoscolus aconitifolius; glibenclamide; phytocomponents; hypoglycaemic.
Document Type : Research Paper
Publication date : July 17, 2020